Hello 

Create Profile

Creating your profile will enable you to submit photos and stories to get published on News24.


Please provide a username for your profile page:

This username must be unique, cannot be edited and will be used in the URL to your profile page across the entire 24.com network.

Facebook Sign-In

Hi News addict,

Join the News24 Community to be involved in breaking the news.

Log in with Facebook to comment and personalise news, weather and listings.

 

How an HIV+ baby was cured

05 March 2013, 11:20

Researchers say they have, for the first time, cured a baby born with HIV - a development that could help improve treatment of babies infected at birth. There is an important technical nuance: researchers insist on calling it a "functional cure" rather than a complete cure.

That is because the virus is not totally eradicated. Still, its presence is reduced to such a low level that a body can control it without the need for standard drug treatment.

But in this new case, the baby girl received nothing more invasive or complex than commonly available antiretroviral drugs. The difference, however, was the dosage and the timing: starting less than 30 hours after her birth.

How the tests were done

The baby was infected by her HIV-positive mother, and her treatment with therapeutic doses of antiretroviral drugs began even before her own positive blood test came back.

The typical protocol for high-risk newborns is to give them smaller doses of the drugs until results from an HIV blood test is available at six weeks old.

Tests showed the baby's viral count steadily declined until it could not longer be detected 29 days after her birth.

The child was given follow-up treatment with antiretrovirals until 18 months, at which point doctors lost contact with her for 10 months. During that period she was not taking antiretrovirals.

Researchers then were able to do a series of blood tests - and none gave an HIV-positive result.

Natural viral suppression without treatment is an exceedingly rare occurrence, seen in fewer than half a percent of HIV-infected adults, known as "elite controllers," whose immune systems are able to rein in viral replication and keep the virus at clinically undetectable levels.

A game changer


Experts on HIV have long wanted to help all HIV patients achieve elite-controller status. Researchers say this new case offers hope as a game-changer, because it suggests prompt antiretroviral therapy in newborns indeed can do that.

Still, they said, their first priority is learning how to stop transmission of the virus from mother to newborn. ARV treatments of mothers currently stop transmission to newborns in 98% of cases, they say.

It is that kind of aggressive treatment that likely yielded the "functional cure," researchers reported.

What researchers call dormant HIV-infected cells often re-start infections in HIV-infected patients within a few weeks after antiretroviral treatment stops, forcing most people who have tested HIV-positive to stay on the drugs for life or risk the illness progressing.

"Prompt antiviral therapy in newborns that begins within days of exposure may help infants clear the virus and achieve long-term remission without lifelong treatment by preventing such viral hideouts from forming in the first place," said lead researcher Deborah Persaud, of Johns Hopkins Children's Center in Baltimore, Maryland.

It appears to be the first time this was achieved in a baby, she said.

"Our next step is to find out if this is a highly unusual response to very early antiretroviral therapy or something we can actually replicate in other high-risk newborns," Persaud pointed out.

The research was funded by the National Institutes of Health and the American Foundation for AIDS Research.

- Health24
 

NEXT ON NEWS24 KENYAX

Read News24’s Comments Policy

Comment on this story
0 comments
Add your comment
Comment 0 characters remaining

Read more from our Users

Submitted by
Wilshere..
Two Jubilee MPs term Duale’s rema...

Two legislators from Jubilee camp Kimani Ngunjiri (Bahati) and David Gikaria (Nakuru East) have termed Adan Duale’s remarks in critiquing the government on curfew as reckless. Read more...

Submitted by
Jonsey
KNUT tells Govt to promote teache...

The Kenya National Union of Teachers has lashed out at the government over low number of teachers set to be promoted. Read more...

Submitted by
William Korir
CORD goes on full offensive at Ju...

Here is the full CORD parliamentary group statement where the coalition has called for steep changes to the security outlook in the country. Read more...

Submitted by
William Korir
Mwangi leads CORD referendum team

Lawyer Paul Mwangi has been named as the leader of a team of experts which will oversee the setting up of a referendum by the CORD coalition. Read more...

Submitted by
William Korir
Sonko calls for end to NSSF wars

Nairobi Senator Gideon Mbuvi 'Sonko' has called on Labour cabinet secretary Kazungu Kambi and COTU boss Francis Atwoli to end turf wars at NSSF. Read more...