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Liquorice root fights tooth decay

05 January 2012, 13:45

Scientists are reporting identification of two substances in liquorice — used extensively in Chinese traditional medicine — that kill the major bacteria responsible for tooth decay and gum disease, the leading causes of tooth loss in children and adults.

In a study in ACS' Journal of Natural Products, they say that these substances could have a role in treating and preventing tooth decay and gum disease.

Stefan Gafner and colleagues explain that the dried root of the liquorice plant is a common treatment in Chinese traditional medicine, especially as a way to enhance the activity of other herbal ingredients or as a flavouring. Despite the popularity of liquorice candy in the US, liquorice root has been replaced in domestic candy with anise oil, which has a similar flavour.

Traditional medical practitioners use dried liquorice root to treat various ailments, such as respiratory and digestive problems, but few modern scientific studies address whether liquorice really works. (Consumers should check with their health care provider before taking liquorice root because it can have undesirable effects and interactions with prescription drugs.)

 To test whether the sweet root could combat the bacteria that cause gum disease and cavities, the researchers took a closer look at various substances in liquorice.

They found that two of the liquorice compounds, licoricidin and licorisoflavan A, were the most effective antibacterial substances. These substances killed two of the major bacteria responsible for dental cavities and two of the bacteria that promote gum disease.

One of the compounds — licoricidin — also killed a third gum disease bacterium.


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